RESEARCH DIRECTIONS
Peptide nanocarriers for targeted delivery of RNAi therapeutics
Although RNAi therapy is promising, siRNAs delivered in vivo face significant barriers including serum instability, renal excretion, and rapid uptake and clearance by the reticuloendothelial system (RES)...
Tailorable drug delivery systems for combination therapy
Advances in nanotechnology have led to the development of multifunctional nanoparticles that allow the delivery of multiple drugs, nucleic acids, targeting moieties, and imaging agents to diseased tissue...
Implantable scaffolds for controlled release of therapeutics
Therapeutic treatment of many disease models, including cancer, requires multiple dosing of therapeutic agents, which often results in harmful side effects such as myelosuppression and cardio- and neurotoxicity due to...
Collaboration: Mathematical Modeling of Endosomal Escape
Although RNAi therapy is promising, siRNAs delivered in vivo face significant barriers including serum instability, renal excretion, and rapid uptake and clearance by the reticuloendothelial system (RES)...
Collaboration: Molecular Dynamic Simulation of Peptide Self-Assembly
Therapeutic treatment of many disease models, including cancer, requires multiple dosing of therapeutic agents, which often results in harmful side effects such as myelosuppression and cardio- and neurotoxicity due to...